NanoString Blog
Category: Digital Spatial Profiling
Digital Spatial Profiling
What is the principle of immunofluorescence?
Immunofluorescence staining was first used in 1942 and has since remained a highly reliable and powerful technique for a wide range of research and diagnostics. The principle of immunofluorescence is…
Digital Spatial Profiling GeoMx DSP
What is a morphology marker?
Understanding tissue morphology is crucial to identify and separate regions of tissue into meaningful biological groupings for image analysis of tissue sections. This is done using morphological markers, most of…
Digital Spatial Profiling
How to download data from the human protein atlas
The Human Protein Atlas (HPA) is a Swedish-based program initiated in 2003 and has become an important resource for both basic and clinical research. It is one of the largest…
Digital Spatial Profiling
What is digital spatial profiling?
The function of biological systems depends on the spatial organization of their cells. Over the past decade, innovative technologies have emerged that can spatially localize and quantify gene expression of…
Digital Spatial Profiling GeoMx DSP Spatial Transcriptomics
FFPE Genomics: a Portal Into the World of Transcriptomic Research?
The emergence of spatial transcriptomics, with its ability to generate highly detailed maps of gene expression with spatial context, is revolutionizing biomedical research, particularly in developmental biology, cancer, immunology, and…
Digital Spatial Profiling GeoMx DSP
GeoMx DSP: What’s in an ROI?
In the field of medical imaging, the region of interest (commonly abbreviated as ROI) is an area within an image that is selected for a particular purpose, including defining boundaries…
Digital Spatial Profiling GeoMx DSP
The Birth of Spatial Genomics
NanoString catalyzed the spatial biology revolution in 2019 with the launch of the GeoMx® Digital Spatial Profiler (DSP), but did you know that the beginnings of this nascent field go…
Digital Spatial Profiling Multiomics Spatial Analysis Spatial Transcriptomics
Spatial Multiomics Identifies New Actionable Therapeutic Targets
Pancreatic cancer represents 3% of the overall cancers in America and yet is responsible for 7% of all cancer deaths. The five-year relative survival rate – the cancer-related death rate…
Digital Spatial Profiling GeoMx DSP Spatial Transcriptomics
A new map for our anatomy: the Spatial Organ Atlas
One year for spring break, we found ourselves in Portland, Oregon. For science-y people, a trip to Portland would be incomplete without a visit to the Oregon Museum of Science…
Digital Spatial Profiling GeoMx DSP nCounter Oncology Spatial Transcriptomics
New approaches to CAR-T therapy
What is CAR-T cell therapy? In the fight against cancer, immunotherapies that enlist and strengthen the power of a patient’s immune system to attack tumor cells have revolutionized treatment paradigms.…
Digital Spatial Profiling nCounter Neuroscience Spatial Transcriptomics
Neurodegenerative disorders and Parkinson’s disease.
The idiom “to lose one’s nerves” is literally true when it comes to neurodegenerative disorders. These disorders are characterized by the progressive loss of disease-specific neural populations in the brain…
Digital Spatial Profiling Spatial Biology
The Importance of Segmentation in Spatial Biology
In a highly interconnected world, clear communication and information across the globe are critical. The same is true at the tissue and cellular levels. Cells communicate through chemical signals such…