NanoString Blog

Category: Neuroscience

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What is Chronic Traumatic Encephalopathy? 

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease affecting people who have suffered repeated concussions and traumatic brain injuries (TBI). CTE was first described in 1928 by Dr. Harrison…

Nirupama Deshpande / March 14, 2022

Neuroscience Spatial Biology Spatial Transcriptomics

The Neuroinflammatory Puzzle of the Autoimmune Disease Multiple Sclerosis

What is Multiple Sclerosis? In 1868, a German physician Leopold Ordenstein and his mentor Jean-Martin Charcot, published a work that fundamentally changed our understanding of the disease Multiple Sclerosis1. For…

Nirupama Deshpande / December 22, 2021
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Neurodegenerative disorders and Parkinson’s disease.

The idiom “to lose one’s nerves” is literally true when it comes to neurodegenerative disorders. These disorders are characterized by the progressive loss of disease-specific neural populations in the brain…

Nirupama Deshpande / December 6, 2021

nCounter Neuroscience Spatial Transcriptomics

Alzheimer’s Disease Pathology: Fear, Confusion, and the Search for a Cure

Alzheimer’s disease pathology: a short sentence loaded with fear, confusion, and incredulity. The word “Alzheimer’s” first appeared in a German psychiatry handbook called “General Psychiatry” on July 15, 1910. This…

Nirupama Deshpande / November 22, 2021
3d model of a neuron


Meet the New Brainiacs in the Fight Against Neurological Diseases

The Liddelow Lab is part of the Neuroscience Institute at NYU Langone. The lab’s research focus is astrocytes and their involvement in human neurological diseases. The team discovered that different…

Laura Tabellini Pierre / September 9, 2021
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Readers’ Favorite Webinars: A Year in Review

NanoString webinars allow you to sit back, relax and listen to a leader in the field talk about his/her research and/or answer your questions.  They have always been a crowd-pleaser,…

Laura Tabellini Pierre / March 2, 2020
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Of Inflammasome and Tauopathies in Mice and Men

Tauopathies are a class of neurodegenerative diseases characterized by the aggregation of tau proteins in neurofibrillary tangles in the human brain. These proteins are associated to microtubules and are found…

Laura Tabellini Pierre / January 27, 2020
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A Strategic Attack Against Neurological Diseases

Neurological diseases are often multifactorial, brought on by a genetic and environmental tug-of-war and resulting in multifaceted clinical presentations. Such etiological complexity has hindered treatment progress and has necessitated well-thought-out…

Amal Katrib / September 3, 2019
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A Systematic Evaluation of Immune Response and Plaque Microenvironment Variation in Alzheimer’s Disease

Alzheimer’s disease (AD) – the most prevalent form of dementia – is associated with defining histopathological features that include amyloid-beta (Aβ) plaque deposition and tau protein aggregation, accompanied by synaptic…

Amal Katrib / August 5, 2019
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New Biology-Driven Drug Discoveries Needed for Treating of Alzheimer’s

Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder that affects millions of people worldwide, leaving behind an immense psychological, emotional, and financial burden on patients, caregivers, and healthcare systems.…

Amal Katrib / June 17, 2019
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Q&A with Dr. Gregory Carter: Developing Computational Strategies and the MODEL-AD Consortium

Gregory Carter, Ph.D., is an Associate Professor at The Jackson Laboratory. His work is focused on developing computational strategies using genetic data to understand complex genetic systems. We recently spoke…

NanoString / March 22, 2019
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Meta-analysis of AMP-AD Datasets Defines the Transcriptional Landscape of Alzheimer’s Disease

The Accelerating Medicines Partnership – Alzheimer’s Disease (AMP-AD) Consortium was formed to accelerate the development of diagnostics and therapeutics for this devastating and complex disease. One roadblock to development is…

Erin Piazza / January 31, 2019