Brain Week at NanoString 2024
Celebrate all things neuroscience with us as we hear throughout the week from four NanoString customers about their work on neurodegenerative disorders and neuroinflammation. Attend two or more webinars and be entered to win an exclusive 50% discount* on a GeoMx® Whole Transcriptome Atlas Starter Pack for 4 slides of Human or Mouse samples!
Monday, March 11:
A Spatial Profiling Approach to Study Neurodegenerative Disease
The brain is highly heterogeneous and the diverse cell types and brain regions show selective vulnerabilities to age-related neurodegenerative disease that can be a challenge to study with high precision. Join us for this first webinar of Brain Week to hear Caitlin S. Latimer, MD, PhD from the University of Washington discuss how she and her colleagues leveraged the spatial-preservation technology of the GeoMx® Digital Spatial Profiler (DSP) to generate highly quantitative spatial proteomic data from specific structures and cell types in the human brain for two research projects. The first project focuses on two different types of genetic Alzheimer’s disease, profiling amyloid plaques and microglia to determine if there are differences in the proteomic profile across cases. The second project is a study of polyproteinopathy in the aged brain, leveraging the use of cell-type specific morphology markers to profile neurons and glial in the setting of sporadic late-onset Alzheimer’s disease with and without comorbid TDP-43 pathology.
Speaker
Caitlin S. Latimer, MD, PhD
Assistant Professor, Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington Medical Center
Tuesday, March 12:
Spatial Profiling the Rhesus Macaque Hippocampus During Chronic SIV Infection
We used the GeoMx DSP to investigate the rhesus macaque (Macaca mulatta) hippocampus during chronic SIV infection. In this webinar, I will present our work highlighting myeloid and lymphoid gene signatures, as well as alterations to metabolic and neurodegenerative pathways in the hippocampus during chronic SIV infection.
Speaker
Sonny R. Elizaldi
PhD Candidate, Immunology Graduate Group, University of California, Davis
Wednesday, March 13:
Stress-Related Transcriptomic Signatures of Alzheimer’s Disease
Join us for this Brain Week webinar to hear Valentina Garbarino, PhD Assistant Professor at the University of Texas, San Antonio discuss how she and her colleagues used an nCounter® Custom CodeSet to probe the utility of a specific stress-related transcriptomic profile, the Conserved Transcriptional Response to Adversity (CTRA), in an early Alzheimer’s disease population. This presentation will cover the study design, methods, and analyses of the results which provide the first data to describe a blood transcriptomic signature that is susceptible to senolytic therapy in an Alzheimer’s population. Dr. Garbarino will also discuss plans to utilize the nCounter technology to streamline analyses as the team prepares to replicate these results within larger and more diverse clinical research populations.
Speaker
Valentina Garbarino, PhD
Assistant Professor, Department of Cell Systems and Anatomy, Biggs Institute for Alzheimer’s and Neurodegenerative Disease, University of Texas, San Antonio
Thursday, March 14:
Single-cell Spatial Multiomics of Tau Neuropathology and Cellular Senescence in Human Brain Sections
Our goal is to identify therapies for Alzheimer’s disease by studying its primary risk factor, advanced age. Profiling post-mortem human Alzheimer’s disease brains using high-resolution methods like GeoMx® DSP and CosMx™ SMI revealed a novel drug target linked to aging. Subsequent studies in transgenic mice, including spatial proteogenomic analyses, confirmed target engagement and efficacy, leading to clinical testing in older adults with Alzheimer’s disease. Evaluation of clinical trial samples with a custom nCounter Gene Expression Panel yielded promising data, supporting Phase 2 clinical testing. This presentation will showcase key findings along this translational path.
Speaker
Miranda Orr, PhD
Assistant Professor, Gerontology and Geriatric Medicine, Wake Forest University School of Medicine
Terms & Conditions
Eligibility and Requirements
In order to be eligible for this giveaway (hereafter referred to as a contest) for a 50% discount on one GeoMx Human or Mouse Whole Transcriptome Atlas (WTA) 4 Slide Starter Pack, you must be actively enrolled at an academic institution or employed at a research facility in a capacity in which you are able to perform research and attend two or more Brain Week webinars during the week of March 11, 2024. One winner will be randomly selected from all webinar attendees who attend two or more Brain Week webinars during the week of March 11, 2024, and the winner must be age 18 or older. The winner will receive a coupon code for a 50% discount on his or her choice of one GeoMx WTA Starter Pack for either Human or Mouse. Members of the immediate families of NanoString employees and directors, and persons living in the same household as such persons, are ineligible for this contest.
Miscellaneous
NanoString Technologies, Inc. is the sponsor of this contest. No purchase is necessary to enter. By attending two or more webinars and being eligible for this contest, you agree to these terms and conditions and that NanoString may process your personal data in accordance with NanoString’s privacy policies available at nanostring.com/privacy. This contest is void where prohibited or otherwise restricted by law. The winner or its applicable institution is responsible for any tax liability incurred by accepting this discount. This is not a “cash in hand” award and the winner has no option to receive any cash payment or alternative award in lieu of a 50% discount on a GeoMx WTA Starter Pack. The award may not be transferred or assigned. NanoString has not made any warranty, representation, or guarantee, express or implied, with respect to this contest, including, without limitation, the quality or fitness of the GeoMx WTA Starter Pack for a particular purpose. If, for any reason, this contest cannot be run as planned for any causes beyond NanoString’s reasonable control, then NanoString reserves the right in its sole discretion to cancel, modify or suspend this contest. These terms and conditions and any action related to this contest are governed by the laws of the State of Washington, USA, without regard to its conflict of law provisions.
