NanoString Blog

CosMx SMI

Tips to optimize sample prep for highly autofluorescent samples on CosMx® SMI

The CosMx® Spatial Molecular Imager (SMI) instrument performs fluorescent imaging to read out in-situ hybridized fluorescent reporters which uniquely identify RNA transcripts. The presence of tissue autofluorescence background may reduce…

Bruker Spatial Biology / May 27, 2025
Green DNA illustration

CosMx SMI

Moving Beyond scRNA-seq: The Power of CosMx Whole Transcriptome

Single-cell RNA sequencing (scRNA-seq) has transformed molecular biology by enabling high-throughput transcriptional profiling at cellular resolution. But as powerful as scRNA-seq is, it comes with trade-offs: loss of spatial information,…

Bruker Spatial Biology / May 25, 2025

Events

Breakthroughs in Spatial Biology: AGBT 2025 Highlights

Discover the future of spatial biology! Read about our AGBT 2025 eBook featuring posters highlighting powerful new breakthroughs EpicIF, CosMx WTX, and InSituDiff, plus on-demand workshop access.

Bruker Spatial Biology / April 14, 2025
FFPE-tissues

CosMx SMI

Revealing Spatial Biology at Whole-Transcriptome Scale: Introducing the CosMx® Human Whole Transcriptome Panel

Learn how CosMx WTX brings whole-transcriptome coverage to every cell in FFPE tissues, uncovering truly groundbreaking spatial biology.

Bruker Spatial Biology / April 2, 2025
Alzheimer_brain_TMA

Neuroscience

Miranda Orr’s Spatial Analyses from Discovery to Validation Reveal Key Processes in Alzheimer’s Disease

Discover Dr. Miranda Orr’s cutting-edge spatial multiomics research in neuroscience, revealing new Alzheimer’s disease processes with advanced proteomic tools.

Bruker Spatial Biology / March 18, 2025
CosMx tissue image

CosMx SMI

Tips when performing CosMx™ data analysis with AtoMx SIP

Single-cell spatial biology opens doors to unprecedented scientific questions requiring the development of new computational workflows and approaches to analyze and interpret data. Whether you are new to single-cell spatial…

Bruker Spatial Biology / October 3, 2024
CosMx tissue image

CosMx SMI

Tips when Generating Single-Cell Spatial Data: Post Run H&E and Antibody Staining

We are excited to share the third installment of tips for successful CosMx™ SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…

NanoString / May 9, 2024
CosMx tissue image

CosMx SMI

Tips When Generating Single-Cell Spatial Data: Sample Selection 

We are excited to share the second installment of tips for successful CosMx™ SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…

NanoString / February 13, 2024

Spatial Biology

NanoString Powered by NVIDIA GPU Technology Accelerates Scientific Discovery and the Age of Spatial Biology

For researchers studying diseases that cruelly take the lives of millions — Alzheimer’s disease, lung, colon, breast, and pancreatic cancer, among others — it has been a long-held dream to…

Sriya Malladi and Meg O'Conor / January 9, 2024
CosMx tissue image

CosMx SMI

Top 3 Tips for Successful CosMx™ SMI Single-cell Spatial Runs at 1000 plex

We are excited to share insights and recommendations to enhance your experience with CosMx™ SMI 1000-plex RNA assays. The quality of single-cell spatial data is influenced by various factors, and…

NanoString / December 13, 2023
Geo location

GeoMx DSP

Getting Started with Your First GeoMx® DSP Experiment: A Step-by-Step Guide

The GeoMx Digital Spatial Profiler (DSP) is a powerful tool for spatial multiomics, the in situ analysis of RNA and protein expression in tissue sections. GeoMx DSP gives you the…

Elizabeth Schneider / December 11, 2023
Rendering of oncology proteins

nCounter Oncology

GEP Signatures Unleashed: The LST for Diffused Large B-Cell Lymphoma, DLBCL, Subtyping and Its Expanding Applications

Gene expression profiling (GEP) signatures, comprising sets of genes characteristic of specific diseases, tissues, cell types, cell states, or biological perturbation, hold significant diagnostic, predictive, and prognostic value, positioning them…

Espy Anguiano / October 31, 2023