NanoString Blog

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CosMx SMI

Why Transcriptomics Matters: Understanding the Value of High-Resolution Spatial Molecular Imaging

As spatial biology reshapes the future of biomedical research, spatial transcriptomics has emerged as one of the most powerful tools for revealing complex tissue biology. Technologies like the CosMx® Spatial…

Bruker Spatial Biology / December 2, 2025

CosMx SMI

Tips to optimize the CosMx Multiomics sample prep for fragile tissues

Tips to optimize the CosMx Multiomics sample prep for fragile tissues The CosMx multiomics platform enables sequential protein and RNA analysis on the same tissue sample, combining a 64-plex protein…

Madhu Augustine / October 12, 2025

Miscellaneous

Understanding Bulk Multiomics: A Technical Introduction

Madhu Augustine / October 5, 2025
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CosMx SMI

The CosMx SMI 2.0: Unmatched advances in single-cell spatial transcriptomics

Explore the CosMx SMI 2.0: Higher RNA sensitivity, whole transcriptome imaging, and faster high fidelity, subcellular spatial transcriptomics.

Bruker Spatial Biology / June 25, 2025

CosMx SMI

Tips to optimize sample prep for highly autofluorescent samples on CosMx® SMI

The CosMx® Spatial Molecular Imager (SMI) instrument performs fluorescent imaging to read out in-situ hybridized fluorescent reporters which uniquely identify RNA transcripts. The presence of tissue autofluorescence background may reduce…

Bruker Spatial Biology / May 19, 2025

CosMx SMI

Moving Beyond scRNA-seq: The Power of CosMx Whole Transcriptome

Compare CosMx SMI versus scRNA-seq and see how spatial transcriptomics reveals more biology in intact tissue and with subcellular resolution.

Bruker Spatial Biology / May 15, 2025
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Events

Breakthroughs in Spatial Biology: AGBT 2025 Highlights

Discover the future of spatial biology! Read about our AGBT 2025 eBook featuring posters highlighting powerful new breakthroughs EpicIF, CosMx WTX, and InSituDiff, plus on-demand workshop access.

Bruker Spatial Biology / April 9, 2025

CosMx SMI

Revealing Spatial Biology at Whole-Transcriptome Scale: Introducing the CosMx® Human Whole Transcriptome Panel

Learn how CosMx WTX brings whole-transcriptome coverage to every cell in FFPE tissues, uncovering truly groundbreaking spatial biology.

Bruker Spatial Biology / March 31, 2025

Neuroscience

Miranda Orr’s Spatial Analyses from Discovery to Validation Reveal Key Processes in Alzheimer’s Disease

Discover Dr. Miranda Orr’s cutting-edge spatial multiomics research in neuroscience, revealing new Alzheimer’s disease processes with advanced proteomic tools.

Bruker Spatial Biology / March 16, 2025
CosMx tissue image

CosMx SMI

Tips when performing CosMx® data analysis with AtoMx SIP

Single-cell spatial biology opens doors to unprecedented scientific questions requiring the development of new computational workflows and approaches to analyze and interpret data. Whether you are new to single-cell spatial…

Bruker Spatial Biology / September 16, 2024
CosMx tissue image

CosMx SMI

Tips when Generating Single-Cell Spatial Data: Post Run H&E and Antibody Staining

We are excited to share the third installment of tips for successful CosMx® SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…

NanoString / May 9, 2024
CosMx tissue image

CosMx SMI

Tips When Generating Single-Cell Spatial Data: Sample Selection 

We are excited to share the second installment of tips for successful CosMx® SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…

NanoString / February 13, 2024