PanCancer Pathways Panel
Helping Your Research
Gene expression profiling can be challenging because reproducibility and data analysis can be extremely demanding. The nCounter PanCancer Pathways Panel offers fast and high-throughput multiplex gene expression analysis solution for human or mouse genes. Each panel comes with 770 genes from 13 cancer-associated canonical pathways to support the understanding of basic cancer biology:
- Measure treatment effects on pathways
- Score pathway deregulation with end-to-end analysis
- Generate follow-up research hypothesis using pathway visualizations
- Rapidly and easily screen samples for biomarker discovery or drug mechanism of action studies
Inspired by systems biology approaches to cancer research, NanoString’s 360 Series Panel Collection gives you a 360° view of gene expression by combining carefully-curated content involved in the biology of the tumor, microenvironment, and the immune response into a single holistic assay. Each panel contains the 18-gene Tumor Inflammation Signature (TIS) that measures a peripherally-suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.
How It Works
The nCounter PanCancer Pathways Panel come with simple workflow of less than 15 minutes hands-on time and streamlined analysis for data in under 24 hours.
*All nCounter Panel products are provided as a CodeSet product sold in increments of 12 reactions. Master Kits (for MAX or FLEX systems) or SPRINT Reagents and Cartridges (for SPRINT) are also required and sold separately.
Highly multiplexed analysis of basic cancer biology and pathway deregulation activity
Measure gene expression with 770 genes representing all major cancer pathways including: Wnt, Hedgehog, apoptosis, cell cycle, RAS, PI3K, STAT, MAPK, Notch, TGF-β, chromatin modification, transcriptional regulation, and DNA damage control
Customizable with up to 55 additional user-defined genes with Panel Plus option
3D-enabled for multi-analyte analysis with Vantage 3D™ Assays
In The Lab
Panel Selection Tool
Find the gene expression panel for your research with easy to use panel proFind Your Panel
Pathway Gene Coverage
Below are brief descriptions of the Pathways included in the PanCancer Pathways Panel. Please click on the name of the pathway to view more information, including detailed information on pathway genes and KEGG pathway gene maps
360 Series Product Comparison
Fully-annotated gene lists in Excel format are available for each of the 360 Panels. The table below compares the biology coverage of the 360 Panels across the tumor, microenvironment, and the immune response to that of the PanCancer Panels Collection.
Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer.
Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part because of technical difficulties in tracing nerve fibers via conventional histological preparations.
Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer.
Purpose: Cancer-associated fibroblasts (CAF) have been implicated as potential mediators of checkpoint immunotherapy response. However, the extensive heterogeneity of these cells has precluded rigorous understanding of their immunoregulatory role in the tumor microenvironment.
Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapy.
Background: Genetically engineered T-cell immunotherapies for adoptive cell transfer (ACT) have emerged as a promising form of cancer treatment, but many of these patients develop recurrent disease. Furthermore, delineating mechanisms of resistance may be challenging since the analysis of bulk tumor profiling can be complicated by spatial heterogeneity.