nCounter® PanCancer
Immune Profiling Panel

Helping Your Research

Perform multiplex gene expression analysis in human or mouse with 770 genes from different immune cell types, common checkpoint inhibitors, CT antigens, and genes covering both the adaptive and innate immune response. The panel measures many features of the immune response to facilitate rapid development of clinical actionable gene expression profiles in the context of cancer immunotherapy.

  • Comprehensive profiling of the immune response optimized for immuno-oncology research
  • Identify tumor-infiltrating lymphocytes (TILs) for the tumor microenvironment
  • Assess mechanistic pathway activity for single or combination studies
  • Customizable with up to 55 additional user-defined genes with Panel Plus option
Medallion for PanCancer Immune Profiling panel

 

The nCounter PanCancer Immune Profiling Panel is for cancer researchers that need more markers than is practical for RT-qPCR but don’t want the broad approach that next-gen sequencing (NGS) offers. The Panel is fully compatible with clinically relevant sample types such as fresh-frozen (FF) tissue, formalin-fixed, paraffin-embedded (FFPE) tumor sections, isolated immune cell populations such as PBMCs, and cell lysates. The panel may be used in conjunction with nCounter Panel Plus products for additional flexibility in experimental design.

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Product Information

Immune Cell Type Gene Coverage
Product Specifications
Product Comparison
Catalog Information
Immune Cell Type Gene Coverage
Product Specifications
Product Comparison

360 Series Product Comparison

Fully-annotated gene lists in Excel format are available for each of the 360 Panels. The table below compares the biology coverage of the 360 Panels across the tumor, microenvironment, and the immune response to that of the PanCancer Panels Collection.

Catalog Information

Related Resources

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Product Bulletin Hallmarks of Cancer – Product Bulletin
Whitepaper Multiplexed Cancer Immune Response Analysis – Whitepaper
Manual/Instructions NanoU Training Videos

Publications

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Assessing Longitudinal Treatment Efficacies and Alterations in Molecular Markers Associated with Glutamatergic Signaling and Immune Checkpoint Inhibitors in a Spontaneous Melanoma Mouse Model

Previous work done by our laboratory described the use of an immunocompetent spontaneous melanoma-prone mouse model, TGS (TG-3/SKH-1), to evaluate treatment outcomes using inhibitors of glutamatergic signaling and immune checkpoint for 18 weeks. We showed a significant therapeutic efficacy with a notable sex-biased response in male mice.

Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones

High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis.

Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer

Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial distribution and cell interactions that shape macrophage tissue roles remain poorly characterized. Here, we spatially resolve five distinct human macrophage populations in normal and malignant human breast and colon tissue and reveal their cellular associations.

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