Stem Cell Therapy and Regenerative Medicine
Solutions for Stem Cell Therapy Research
From measuring stem cell pluripotency to deep molecular characterization of pluripotent stem cells, assessing cell culture conditions and exploring organoid tissue function, together we can advance the field of regenerative medicine and improve the human condition.
- Deeply characterize pluripotent stem cells
- Optimize stem cell development
- Evaluate viability, confirm functionality, & determine pluripotency
- Detect mycoplasma contamination
- Assess cell culture conditions
- Fully elucidate alterations in metabolic pathways, signaling pathways, and cell stress
Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection.
We have shown that calcium-activated potassium (KCa)-channels regulate fundamental progenitor-cell functions, including proliferation, but their contribution to cell-therapy effectiveness is unknown. Here, we test the participation of KCa-channels in human heart explant-derived cell (EDC) physiology and therapeutic potential.
Translational investigation of electrophysiology in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) patients are at increased risk of ventricular arrhythmias and sudden cardiac death, which can occur even in the absence of structural changes of the heart. HCM mouse models suggest mutations in myofilament components to affect Ca2+ homeostasis and thereby favor arrhythmia development.
Reactivation of a developmentally silenced embryonic globin gene.
The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the hemoglobinopathies, the most common single gene disorders.